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PHOENIX (AP) - Buffalo Bills defensive end Mark Anderson is out indefinitely after hurting his left knee in what becomes the latest blow for a porous defense.

General manager Buddy Nix told the team's website Wednesday that the injury is not season-ending, but Anderson will miss significant time. Nix said Anderson is visiting specialist James Andrews to determine the severity of the injury.

"He looks like he needs surgery and he is going to be out, I do not know how long. Have to wait and see. They are going to tell us after they go in and look at it," said Bills head coach Chan Gailey.

Anderson had difficulty putting any weight on his left leg after being hurt in the second half of a 45-3 loss at San Francisco on Sunday.

"He has been a very good addition to our football team. You hate to lose people that have his kind of energy and have been playing the way that he has been playing. It hurts your depth, it hurts your pass rush, and it hurts every little thing there. Next guy in line has to step up," said Gailey.

The Bills attempted to improve their defense by signing Anderson and Mario Williams in March. The plan's been unsuccessful so far.



Buffalo (2-3), which plays at Arizona (4-1) on Sunday, has allowed a combined 97 points and 1,201 yards in its past two games.

(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)

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