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2-On-Your-Side's Adam Benigni and Sal Maiorana of the Rochester Democrat and Chronicle discuss the many issues and challenges the Bills face as they prepare for Sunday's game at San Francisco.

The topics range from the struggles of the defense, to the inconsistency of quarterback Ryan Fitzpatrick. The Bills had a 21-7 third quarter lead against New England at home this past Sunday, and gave up six consecutive second half touchdowns to Tom Brady and the Patriots in a 52-28 loss to fall to 1-2 on the season.

San Francisco is one of the best teams in the NFL, with one of the most physical defenses, and are off to a 3-1 start.