| Week 6 Scoreboard: |
|
| St. Mary's/Lanc. 33 - St. Francis 7 |
| Bishop Timon-St. Jude 34 - Cardinal O'Hara 7 |
| Niagara Falls 15 - Kenmore West 14 |
| Hutch-Tech 28 - Riverside 8 |
| Kenmore East 20 - Starpoint 19 |
| Grand Island 14 - Niagara-Wheatfield 7 |
| Sweet Home 56 - Williamsville North 18 |
| JFK 48 - Gowanda 0 |
| Ellicottville/WV 35 - Panama 8 |
| Sherman/Ripley 26 - Franklinville 7 |
| Cleveland Hill 38 - Amherst 8 |
| St. Joe's 30 - Lockport 25 |
| Wilson 12 - Newfane 6 |
| Clarence 35 - West Seneca West 11 |
| Frontier 22 - Lancaster 16 |
| Jamestown 35 - Orchard Park 28 |
| McKinley 48 - North Tonawanda 32 |
| Iroquois 29 - Hamburg 22 |
| South Park 22 - Bennett 14 |
| West Seneca East 34 - Lake Shore 6 |
| Williamsville South 50 - Williamsville East 14 |
| Eden 22 - Pioneer 20 |
| Olean 34 - East Aurora 0 |
| Springville 20 - Dunkirk 0 |
| Alden 41 - Medina/Lyndonville 20 |
| Barker/Roy-Hart 33 - Albion 30 |
| Depew 35 - East 8 |
| Burgard 20 - Tonawanda 13 |
| Cheektowaga 52 - Lew-Port 6 |
| Maryvale 49 - Lackawanna 21 |
| Akron 27 - Fredonia 10 |
| Cassadaga Valley 14 - Southwestern 6 |
| Salamanca 41 - Falconer 8 |
| Cattaraugus/LV 16 - I-Prep @ Grover 0 |
| Maple Grove 21 - Portville 0 |
| Randolph 35 - Chautauqua Lake 6 |
| Silver Creek 34 - Frewsburg 12 |
| Clymer 32 - Pine Valley 6 |
| Nichols 43 - University Prep. (V) 22 |
| Allegany-Limestone 50 - Finney (V) 0 |
| Westfield/Brocton 33 - Forestville 0 |
| Canisius 35 - Aquinas (V) 7 |