| Week 5 Scoreboard: |
|
| Canisius 51 - St. Francis 18 |
| Lockport 36 - Kenmore West 21 |
| Niagara Falls 21 - Hutch-Tech 6 |
| Orchard Park 34 - Lancaster 24 |
| Grand Island 26 - Williamsville North 21 |
| McKinley 44 - Kenmore East 0 |
| Starpoint 48 - North Tonawanda 7 |
| Sweet Home 48 - Niagara-Wheatfield 6 |
| Bennett 28 - Williamsville East 25 |
| Olean 28 - Eden 14 |
| Albion 20 - Newfane 12 |
| Clymer 55 - Panama 7 |
| Pine Valley 27 - Forestville 21 |
| Nichols 37 - C.G. Finney (V) 20 |
| Cardinal O'Hara 49 - University Prep. (V) 30 |
| Timon-St. Jude 28 - St. Mary's/Lanc. 21 |
| Frontier 35 - Jamestown 28 |
| Iroquois 29 - Williamsville South 26 |
| South Park 38 - Lake Shore 14 |
| West Seneca East 34 - Hamburg 14 |
| Springville 14 - Pioneer 13 |
| Alden 34 - Depew 13 |
| Medina/Lyndonville 34 - East 18 |
| Burgard 20 - Lackawanna 14 |
| Lew-Port 47 - Maryvale 32 |
| Tonawanda 26 - Amherst 6 |
| Fredonia 15 - Cleveland Hill 8 |
| Wilson 32 - Akron 29 |
| Allegany-Limestone 34 - Southwestern 13 |
| Westfield/Brocton 18 - Cassadaga Valley 0 |
| Chautauqua Lake 16 - Frewsburg 6 |
| Maple Grove 38 - I-Prep. @ Grover 0 |
| Randolph 38 - Portville 6 |
| Silver Creek 30 - Catt./LV 20 |
| Ellicottville/WV 34 - Sherman/Ripley 21 |
| Barker/Roy-Hart 32 - West Seneca West 31 |
| Cheektowaga 44 - Dunkirk 26 |
| Clarence 42 - Riverside 12 |
| Franklinville 7 - Falconer 6 |
| JFK 28 - East Aurora 14 |
| Salamanca 64 - Gowanda 8 |
| St. Joe's 27 - Aquinas (V) 14 |