| Week 4 Scoreboard: |
|
| St. Joe's 35 - Cardinal O'Hara 0 |
| Kenmore West 30 - Riverside 6 |
| Lockport 49 - Niagara Falls 9 |
| Starpoint 49 - Niagara-Wheatfield 14 |
| Hamburg 28 - Bennett 12 |
| Alden 31 - East 6 |
| Barker/Roy-Hart 30 - Newfane 20 |
| Pioneer 42 - Olean 6 |
| Cleveland Hill 16 - Wilson 13 |
| Clymer 37 - Forestville 6 |
| Sherman/Ripley 38 - Panama 27 |
| Canisius 14 - Walsh Jesuit (Ohio) 7 |
| Lew-Port 28 - South Park 27 |
| St. Mary's 41 - Ellicottville/West Valley 0 |
| Timon/St. Jude 16 - Wilson Magnet (V) 0 |
| Williamsville East 21 - Williamsville North 19 |
| Clarence 25 - Lancaster 21 |
| Jamestown 42 - West Seneca West 8 |
| Orchard Park 27 - Frontier 10 |
| North Tonawanda 31 - Kenmore East 28 |
| Sweet Home 28 - McKinley 20 |
| Iroquois 35 - Lake Shore 7 |
| West Seneca East 28 - Williamsville South 7 |
| East Aurora 14 - Springville 6 |
| Eden 35 - Dunkirk 21 |
| Depew 63 - Medina/Lyndonville 26 |
| Burgard 20 - Maryvale 13 |
| Cheektowaga 60 - Amherst 23 |
| Lackawanna 41 - Tonawanda 21 |
| Fredonia 56 - Gowanda 8 |
| JFK 26 - Akron 22 |
| Southwestern 47 - Salamanca 46 (OT) |
| Westfield/Brocton 18 - Falconer 6 |
| Frewsburg 22 - Cattaraugus/LV 20 |
| Maple Grove 21 - Chautauqua Lake 0 |
| Portville 37 - Silver Creek 14 |
| Randolph 40 - I. Prep @ Grover 0 |
| Franklinville 25 - Pine Valley 13 |
| Grand Island 24 - Hutch-Tech 6 |