| Week 3 Scoreboard: |
|
| St. Mary's 40 - Cardinal O'Hara 18 |
| St. Joe's 28 - St. Francis 21 |
| Lockport 38 - Hutch Tech 8 |
| Grand Island 31 - Starpoint 14 |
| Kenmore East 21 - Niagara-Wheatfield 0 |
| Williamsville North 20 - North Tonawanda 14 |
| West Seneca East 35 - South Park 18 |
| Williamsville East 14 - Iroquois 7 |
| Williamsville South 42 - Bennett 14 |
| Olean 18 - Southwestern 3 |
| Cassadaga Valley 21 - Falconer 0 |
| Silver Creek 22 - I-Prep @ Grover 7 |
| Panama 40 - Forestville 15 |
| Burgard 16 - Springville 12 |
| JFK 33 - University Prep. (V) 6 |
| Sherman/Ripley 26 - Westfield/Brocton 18 |
| Sweet Home 28 - Kenmore West 6 |
| Aquinas (V) 35 - Bishop Timon/St. Jude 7 |
| Niagara Falls 17 - Riverside 14 |
| Frontier 27 - Clarence 24 |
| Jamestown 28 - Lancaster 22 |
| Orchard Park 48 - West Seneca West 8 |
| Hamburg 28 - Lake Shore 7 |
| Dunkirk 16 - East Aurora 14 |
| Alden 36 - Albion 14 |
| Depew 33 - Barker/Roy Hart 14 |
| Medina/Lyndonville 50 - Newfane 6 |
| Cheektowaga 28 - Lackawanna 7 |
| Lew-Port 36 - Amherst 32 |
| Maryvale 28 - Tonawanda 7 |
| Wilson 20 - Fredonia 7 |
| Chautauqua Lake 40 - Cattaraugus/LV 6 |
| Maple Grove 27 - Randolph 14 |
| Portville 16 - Frewsburg 12 |
| Clymer 6 - Franklinville 0 |
| Ellicottville/West Valley 24 - Pine Valley 0 |
| Canisius 55 - McKinley 30 |
| Eden 48 - Gowanda 0 |
| Pioneer 16 - East 14 |