| Week 2 Scoreboard: |
|
| West Seneca West 34 - Lancaster 7 |
| Iroquois 40 - South Park 26 |
| Williamsville South 35 - Hamburg 20 |
| Eden 19 - Springville 13 (3 OT) |
| Pioneer 42 - East Aurora 22 |
| East 20 - Albion 16 |
| Medina/Lyndonville 38 - Baker/Roy-Hart 22 |
| Lew-Port 38 - Tonawanda 14 |
| Maryvale 42 - Amherst 21 |
| Salamanca 24 - Cassadaga Valley 8 |
| Westfield/Brocton 27 - Southwestern 0 |
| Chautauqua Lake 12 - Portville 6 |
| Frewsburg 27 - I-Prep. @ Grover 0 |
| Maple Grove 30 - Cattaraugus/LV 6 |
| Frankinville 34 - Forestville 14 |
| Akron 50 - University Prep. (V) 12 |
| Alden 34 - Niagara-Wheatfield 6 |
| Allegany-Limestone 13 - Fredonia 0 |
| Falconer 24 - Panama 12 |
| Lackawanna 14 - Lake Shore 0 |
| St. Joe's 43 - Bennett 14 |
| Steubenville (Oh.) 21 - Timon-St. Jude 7 |
| Mynderse (V) 41 - Nichols 34 |
| Sherman 35 - Pine Valley 7 |
| Randolph 13 - Silver Creek 12 |
| Kenmore West 21 - Hutch-Tech 14 |
| Orchard Park 49 - Clarence 14 |
| Grand Island 35 - North Tonawanda 21 |
| McKinley 24 - Williamsville North 12 |
| Sweet Home 41 - Kenmore East 6 |
| Dunkirk 34 - Olean 28 |
| Depew 53 - Newfane 0 |
| Cheektowaga 20 - Burgard 14 (OT) |
| Cleveland Hill 50 - Gowanda 0 |
| JFK 31 - Wilson 26 |
| Clymer 20 - Ellicottville/West Valley 14 (OT) |
| Canisius 30 - St. Mary's/Lanc. 27 |
| Batavia (V) 35 - Cardinal O'Hara 8 |
| Frontier 35 - Riverside 16 |
| Jamestown 35 - Niagara Falls 7 |
| Holy Trinity (L.I.) 42 - St. Francis 41 |
| Lockport 31 - Starpoint 6 |