| Week 1 Scoreboard: |
|
| Grand Island 26 - Kenmore West 14 |
| Starpoint 23 - Williamsville North 20 |
| Eden 28 - East Aurora 26 |
| Maple Grove 23 - Silver Creek 14 |
| Panama 40 - Franklinville 6 |
| Sherman/Ripley 32 - Clymer 0 |
| Aquinas (V) 44 - St. Francis 7 |
| Canisius 36 - McQuaid (V) 17 |
| Cassadaga Valley 40 - Pine Valley 12 |
| Edison (V) 21 - Cardinal O'Hara 12 |
| Nichols 14 - Canisteo-Greenwood (V) 7 |
| Orchard Park 42 - Lockport 21 |
| St. Joe's 56 - Wilson Magnet (V) 34 |
| St. Mary's/Lancaster 16 - Franklin (V) 14 |
| West Seneca West 28 - Frontier 12 |
| McKinley 52 - Niagara-Wheatfield 0 |
| Sweet Home 46 - North Tonawanda 19 |
| South Park 18 - Hamburg 6 |
| Williamsville East 40 - Lake Shore 19 |
| West Seneca East 48 - Bennett 6 |
| Pioneer 21 - Dunkirk 12 |
| Alden 42 - Barker/Roy-Hart 13 |
| Depew 42 - Albion 0 |
| East 36 - Newfane 6 |
| Amherst 31 - Lackawanna 20 |
| Burgard 42 - Lew-Port 26 |
| Cheektowaga 53 - Tonawanda 32 |
| Fredonia 28 - JFK 14 |
| Wilson 48 - Gowanda 0 |
| Southwestern 24 - Falconer 0 |
| Allegany-Limestone 34 - Westfield/Brocton 6 |
| Chautauqua Lake 36 - I. Prep/Grover 12 |
| Frewsburg 35 - Randolph 24 |
| Ellicottville/West Valley 36 - Forestville 6 |
| Akron 34 - Medina/Lyndonville 22 |
| Bishop Timon/St. Jude 21 - Williamsville South 14 |
| Bradford (Pa.) 20 - Olean 7 |
| Cleveland Hill 34 - Maryvale 16 |
| Iroquois 15 - Hutch-Tech 14 |
| Jamestown 27 - Kenmore West 8 |
| Lancaster 16 - Niagara Falls 10 |
| Portville 20 - Cattaraugus/Little Valley 0 |
| Salamanca 7 - Springville 6 |
| Clarence 34 - West Genesee 33 |
| Auburn 50 - Riverside 20 |