| Scores |
| Week 5 |
| |
| St. Joes 27 - St. Francis 20 |
| Niagara Falls 41 - Riverside 0 |
| Kenmore West 27 - Lockport 7 |
| Orchard Park 44 - Clarence 13 |
| Sweet Home 52 - Kenmore East 8 |
| Starpoint 32 - McKinley 25 |
| Williamsville North 7 - Grand Island 0 |
| Pioneer 17 - Eden 0 |
| Maryvale 29 - Burgard 22 |
| Fredonia 26 - Cleveland Hill 16 |
| Southwestern 12 -Cassadaga Valley 0 |
| Sherman 22 - Clymer 12 |
| Ellicottville 18 - Forestville 6 |
| JFK 41 - Nichols 19 |
| Cheektowaga 23 - St. Mary's/Lancaster 10 |
| Walsh Jesuit (Ohio) 45 - Canisius 27 |
| Niagara Wheatfield 21 - Hutch-Tech 20 |
| Jamestown 47 - Lancaster 14 |
| Frontier 23 - West Seneca West 13 |
| North Tonawanda 41 - Williamsville East 18 |
| Amherst 21 - Hamburg 20 (OT) |
| Bennett 43 - Iroquois 31 |
| Lake Shore 29 - South Park 6 |
| Williamsville South 28 - West Seneca East 7 |
| Olean 27 - Dunkirk 21 |
| Albion 20 - Newfane 14 |
| Alden 14 - Depew 13 |
| Medina 21 - East 14 |
| Tonawanda 35 - Lew-Port 7 |
| Akron 36 - Wilson 8 |
| Catt./LV 28 - Falconer 14 |
| Salamanca 35 - Westfield 13 |
| Maple Grove 38 - Randolph 6 |
| Silver Creek 27 - I-Prep/Grover 6 |
| Panama 28 - Franklinville 7 |
| Chautauqua Lake 44 - Pine Valley 7 |
| Allegany-Limestone 28 - Portville 15 |
| Frewsburg 50 - Cardinal O'Hara 12 |
| Gowanda 18 - Lafayette 14 |
| Lackawanna 39 - East Aurora 6 |
| Timon-St. Jude 35 - Springville 16 |