CLASS AA:
- Clarence @ Lockport
- Hutch-Tech @ Jamestown
- Frontier @ Niagara Falls
- Kenmore West @ Orchard Park
CLASS A:
- Starpoint @ West Seneca East
- South Park @ Sweet Home
- Williamsville South @ McKinley
- Grand Island @ Iroquois
CLASS B:
- Medina/Lyndonville @ Alden
- Lew-Port @ Cheektowaga
- Burgard @ Depew
- Pioneer/Sprinville @ Eden
CLASS C:
- Cassadaga Valley @ Cleveland Hill
- Wilson @ Salamanca
- Fredonia @ Allegany/Limestone
- Westfield/Brocton @ JFK
CLASS D:
- I-Prep @ Maple Grove
- Cattaraugus/Little Valley @ Randolph
- Silver Creek @ Chautauqua Lake
- Frewsburg @ Portville
CLASS DD:
- Panama @ Clymer
- Sherman/Ripley @ Ellicottville/West Valley
Note: Semi-Finals are in week 8 for Class DD; bye week in 9. The Title game will be played at Ralph Wilson Stadium in week 10.