ORCHARD PARK, NY — It's no secret Tom Brady has owned the Bills since taking the reins in New England back in 2001. He's 26-3 all-time against Buffalo and has thrown 66 touchdown passes against the Bills.

And as Bills coach Sean McDermott gets ready to face the Patriots for the first time as a head coach, he acknowledges the challenges this team poses.

"Obviously the matchups are important. You do the best you can. I don’t know if anybody has ever stopped him. I don’t know if anybody has ever stopped their offense. They’ve got weapons, they’ve got matchup weapons all over the board, and so they’re a talented group," McDermott said.

"Well, it's a headache. A lot of long hours, a lot of communication between coaches and coaches and players and players to players and so they challenge you from a preparation standpoint. They challenge you off the field, they challenge you on the field so they're a good football team," McDermott said.

And their offense is just one aspect of it, the Patriots defense has improved to one of the best in the league since Week 4.

Through the first four weeks of the season, they gave up 32 points-per-game but since then, they only allow 13.1, which leads the league.