ORCHARD PARK, NY - It's no surprise the Bills ran wild against the league's second-worst run defense. The 49ers were just no match for the Bills' ground game and LeSean McCoy.

McCoy rushed for 140 yards and three touchdowns against the 49ers for his first 3-TD game since December of 2011.

"I think this year we're rolling. The guys up front are really blocking well, I'm healthy, Coach Lynn's calling some great plays so it's that simple," LeSean McCoy said.

As a team, the Bills rushed for 312 yards, the most in a game for Buffalo since November of 1992.