ORCHARD PARK, NY - The Patriots have never been swept by a division opponent since Tom Brady became their starter in 2001. The Bills have a chance to change that on Sunday after beating them in Foxboro earlier this month but this time around, Tom Brady is back under center.

"You know it's a big challenge any time you go against him. Obviously if he knows what you're in, you're in trouble," Rex Ryan explained.

Tom Brady has owned the Bills. He's 25-3 all-time and has thrown more touchdowns (62) and had more 300-yard games (9) against Buffalo than any other team.

"We have to do a good job of trying to move him around, try to confuse him if you can confuse him. And we have to get our hands on some balls if possible and create some turnovers," Bills linebacker Lorenzo Alexander said.

The Bills won the first meeting 16-0 on the road while Tom Brady served the last game of his Deflategate suspension. Rookie Jacoby Brissett started at quarterback.